Two meta-analyses published in 2008 (Kirsch) and 2010 (Fournier) found that in mild and moderate depression, the effect of SSRIs is small or none compared to placebo, while in very severe depression the effect of SSRIs is between 'relatively small' and 'substantial'.There has been controversy regarding the efficacy of SSRIs in treating depression depending on its severity and duration. They recommend against their routine use in those who have chronic health problems and mild depression. Depression Īntidepressants are recommended by the UK National Institute for Health and Care Excellence (NICE) as a first-line treatment of severe depression and for the treatment of mild-to-moderate depression that persists after conservative measures such as cognitive therapy.

They are also frequently used to treat depersonalization disorder, although with varying results. The main indication for SSRIs is major depressive disorder however, they are frequently prescribed for anxiety disorders, such as social anxiety disorder, generalized anxiety disorder, panic disorder, obsessive–compulsive disorder (OCD), eating disorders, chronic pain, and, in some cases, for posttraumatic stress disorder (PTSD).

2.12.2 Neuropsychiatric effects in offspring.

2.12.1 Persistent pulmonary hypertension.

The efficacy of SSRIs in mild or moderate cases of depression has been disputed and may or may not be outweighed by side effects, especially in adolescent populations. SSRIs are the most widely prescribed antidepressants in many countries.

They have varying degrees of selectivity for the other monoamine transporters, with pure SSRIs having strong affinity for the serotonin transporter and only weak affinity for the norepinephrine and dopamine transporters. SSRIs increase the extracellular level of the neurotransmitter serotonin by limiting its reabsorption (reuptake) into the presynaptic cell. Selective serotonin reuptake inhibitors ( SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder, anxiety disorders, and other psychological conditions. Major depressive disorder, anxiety disorders Serotonin-specific reuptake inhibitors, serotonergic antidepressants Serotonin, the neurotransmitter that is involved in the mechanism of action of SSRIs.

Synonyms for obsessed